Affiliation:
1. Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane QLD 4072 Australia
2. School of Environment and Science Griffith University Brisbane Queensland 4111 Australia
3. Queensland Micro‐ and Nanotechnology Centre Griffith University Nathan QLD 4111 Australia
Abstract
AbstractMatrix metalloproteinases (MMPs) are a class of zinc‐dependent endopeptidases that play important roles in disease progression. High expression of MMPs is associated with various diseases, including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. For better understanding the roles of MMPs in these diseases’ development and the potential in early diagnosis and treatment monitoring, a number of sensors have recently been developed for MMPs detection in vitro and in vivo. These sensors are designed mainly based on the exploration of MMPs’ molecular structure and enzymatic activity. This review seeks to provide a summary for the development and application of the sensors for the detection of MMPs in the past three years. The research hotspots, current challenges, and further research directions in this field are also discussed.
Funder
National Health and Medical Research Council
China Scholarship Council
Subject
Industrial and Manufacturing Engineering,Mechanics of Materials,General Materials Science
Cited by
6 articles.
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