Determination of the partition coefficient of isoquinoline alkaloids from Chelidonium majus by reversed phase thin layer chromatography-Reference-Cited by-同舟云学术

Determination of the partition coefficient of isoquinoline alkaloids from Chelidonium majus by reversed phase thin layer chromatography

Published:2020 Issue:18 Volume:44 Page:7484-7489
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Czeszak Aleksandra¹²³⁴⁵,Resztak Matylda⁶⁷⁸⁹⁵^ORCID,Czyrski Andrzej⁶⁷⁸⁹⁵,Nowak Izabela¹²³⁴⁵

Affiliation:

1. Laboratory of Applied Chemistry

2. Faculty of Chemistry

3. Adam Mickiewicz University in Poznań

4. 61-614 Poznań

5. Poland

6. Chair and Department of Physical Pharmacy and Pharmacokinetics

7. Faculty of Pharmacy

8. University of Medical Sciences in Poznań

9. 60-781 Poznań

Abstract

Determination of the partition coefficient (log P) of alkaloids by the RP-TLC method at different pH values. Distribution coefficient (log D) values were calculated. The investigated chlorides were found to be the most lipophilic of the compounds studied.

Funder

National Center for Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ00307G

Reference43 articles.

1. The influence of lipophilicity in drug discovery and design

2. Lipophilicity estimation of statins as a decisive physicochemical parameter for their hepato-selectivity using reversed-phase thin layer chromatography

3. Lipophilic properties of anti-Alzheimer's agents determined by micellar electrokinetic chromatography and reversed-phase thin-layer chromatography

4. Influence of organic modifier and separation modes for lipophilicity assessment of drugs using thin layer chromatography indices

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