The maternal-fetal transfer of passive immunity as a mechanism of transplacental nanoparticle drug delivery for prenatal therapies

Author:

Tse Wai Hei123ORCID,Higgins Sean12,Patel Daywin123,Xing Malcolm4ORCID,West Adrian R.23ORCID,Labouta Hagar I.25ORCID,Keijzer Richard123

Affiliation:

1. Departments of Surgery, Division of Pediatric Surgery and Pediatrics & Child Health, University of Manitoba, R3E 0W2, Manitoba, Canada

2. Children's Hospital Research Institute of Manitoba, Winnipeg, R3E 3P4, Manitoba, Canada

3. Department of Physiology & Pathophysiology, University of Manitoba, R3E 0W2, Manitoba, Canada

4. Department of Mechanical Engineering, University of Manitoba, R3T 2N2, Manitoba, Canada

5. Apotex Centre, College of Pharmacy, University of Manitoba, R3E 3T5, Manitoba, Canada

Abstract

Nanoparticles surface-modified with IgG isoform antibodies as a potential platform for the transplacental targeted delivery of therapeutics to the developing fetus.

Funder

Research Manitoba

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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