Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

Author:

Lenders Vincent1ORCID,Koutsoumpou Xanthippi1ORCID,Phan Philana2,Soenen Stefaan J.13ORCID,Allegaert Karel4567,de Vleeschouwer Steven8910,Toelen Jaan6711,Zhao Zongmin2,Manshian Bella B.1ORCID

Affiliation:

1. Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, Belgium

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

3. NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, Belgium

4. Department of Hospital Pharmacy, Erasmus MC University Medical Center, CN Rotterdam, 3015, The Netherlands

5. Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, B3000 Leuven, Belgium

6. Leuven Child and Youth Institute, KU Leuven, 3000 Leuven, Belgium

7. Woman and Child, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium

8. Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium

9. Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Leuven, Belgium

10. Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium

11. Department of Pediatrics, University Hospitals Leuven, 3000 Leuven, Belgium

Abstract

This review discusses the strengths and shortcomings of different strategies to facilitate NP transport across barriers of organs and highlights key findings that can stimulate further advances in this field.

Funder

Fonds Wetenschappelijk Onderzoek

Horizon 2020 Framework Programme

KU Leuven

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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