Systematic synthesis of novel phosphoglycolipid analogues as potential agonists of GPR55-Reference-Cited by-同舟云学术

Systematic synthesis of novel phosphoglycolipid analogues as potential agonists of GPR55

Published:2020 Issue:41 Volume:18 Page:8467-8473
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Abe Junpei¹²³⁴^ORCID,Guy Adam T.⁵⁶⁴^ORCID,Ding Feiqing⁷⁸⁹¹⁰^ORCID,Greimel Peter⁵⁶⁴^ORCID,Hirabayashi Yoshio¹¹⁶⁴,Kamiguchi Hiroyuki⁵⁶⁴^ORCID,Ito Yukishige¹²³⁴¹¹^ORCID

Affiliation:

1. Graduate School of Science

2. Osaka University

3. Toyonaka

4. Japan

5. RIKEN Center for Brain Research

6. Wako

7. School of Pharmaceutical Sciences (Shenzhen)

8. SunYat-sen University

9. Guangzhou 510275

10. China

11. RIKEN Cluster for Pioneering Research

Abstract

In order to develop novel agonists of GPR55, we carried out the systematic synthesis of lysophosphatidyl glucoside (LPGlc) analogues having squaryldiamide as a surrogate of phosphodiester, by means of consecutive amidation of diethyl squarate.

Funder

RIKEN

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Mizutani Foundation for Glycoscience

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01756F

Reference61 articles.