Water biocatalytic effect attenuates cytochrome P450-mediated carcinogenicity of diethylnitrosamine: A computational insight-Reference-Cited by-同舟云学术

Water biocatalytic effect attenuates cytochrome P450-mediated carcinogenicity of diethylnitrosamine: A computational insight

Published:2021 Issue:41 Volume:19 Page:9031-9042
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kamel Emadeldin M.¹²^ORCID,Lamsabhi Al Mokhtar²³^ORCID

Affiliation:

1. Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt

2. Departamento de Química, Módulo 13, Universidad Autónoma de Madrid, Campus de Excelencia UAM-CSIC Cantoblanco, 28049 Madrid, Spain

3. Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain

Abstract

The mechanism-based mutagenicity and carcinogenicity of diethylnitrosamine (DEN) are believed to act through interactions with cytochrome P450 (P450) enzymes.

Funder

Ministerio de Ciencia, Innovación y Universidades

Consejería de Educación, Juventud y Deporte, Comunidad de Madrid

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01439K

Reference54 articles.

1. Cytochrome p450 enzymes in the generation of commercial products

2. M. A.Correia and P. R.Ortiz de Montellano , in Cytochrome P450: Structure, Mechanism, and Biochemistry , ed. P. R. Ortiz de Montellano , Springer US , Boston, MA , 2005 , pp. 247–322

3. The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

4. Cytochrome P450 and Chemical Toxicology

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