Rapid assembly of potent type II dehydroquinase inhibitorsvia “Click” chemistry-Reference-Cited by-同舟云学术

Rapid assembly of potent type II dehydroquinase inhibitorsvia “Click” chemistry

Published:2010 Issue:4 Volume:1 Page:271-275
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Tran Anh Thu¹²³⁴,Cergol Katie M.¹²³⁴,Britton Warwick J.⁵²⁶⁷⁸,Imran Bokhari Syed Ali⁹¹⁰¹¹,Ibrahim Musadiq⁹¹⁰¹¹,Lapthorn Adrian J.⁹¹⁰¹¹,Payne Richard J.¹²³⁴

Affiliation:

1. School of Chemistry

2. The University of Sydney

3. Sydney

4. Australia

5. Faculty of Medicine, Blackburn Building

6. NSW 2006

7. Australia and Mycobacterial Research Program

8. Centenary Institute

9. Department of Chemistry and Division of Biochemistry and Life Science

10. University of Glasgow

11. UK

Abstract

The rapid synthesis of a library of potent type II dehydroquinase inhibitors is described. Inhibitors were prepared via a key quinate-derived ene-yne intermediate using Cu(i)-catalysed azide-alkyne cycloaddition (CuAAC) chemistry with a variety of aryl- and heteroaryl-azides.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2010/MD/C0MD00097C

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