Synthesis, absolute configuration and in vitro cytotoxicity of deschloroketamine enantiomers: rediscovered and abused dissociative anaesthetic-Reference-Cited by-同舟云学术

Synthesis, absolute configuration and in vitro cytotoxicity of deschloroketamine enantiomers: rediscovered and abused dissociative anaesthetic

Published:2018 Issue:24 Volume:42 Page:19360-19368
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Jurásek Bronislav¹²³⁴⁵^ORCID,Králík František⁶²³⁴,Rimpelová Silvie⁷²³⁴,Čejka Jan⁸²³⁴^ORCID,Setnička Vladimír⁶²³⁴,Ruml Tomáš⁷²³⁴,Kuchař Martin¹²³⁴⁵,Kohout Michal⁹²³⁴^ORCID

Affiliation:

1. Forensic Laboratory of Biologically Active Substances

2. University of Chemistry and Technology Prague

3. Prague 6

4. Czech Republic

5. Department of Chemistry of Natural Compounds

6. Department of Analytical Chemistry

7. Department of Biochemistry and Microbiology

8. Department of Solid State Chemistry

9. Department of Organic Chemistry

Abstract

Deschloroketamine has been synthesized, the absolute configuration of enantiomers elucidated and the in vitro cytotoxicity of the enantiomers determined using nine different cell lines.

Funder

Ministerstvo Vnitra České Republiky

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ03107J

Reference48 articles.

1. European Monitoring Centre for Drugs and Drug Addiction and Europol , European Drug Report 2017: Trends and Developments , Luxembourg , 2017

2. Ketamine by continuous infusion for sedation in the pediatric intensive care unit