Anticancer metallohelices: nanomolar potency and high selectivity-Reference-Cited by-同舟云学术

Anticancer metallohelices: nanomolar potency and high selectivity

Published:2016 Issue:2 Volume:7 Page:951-958
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kaner Rebecca A.¹²³⁴⁵,Allison Simon J.⁶⁷⁸⁴,Faulkner Alan D.¹²³⁴,Phillips Roger M.⁶⁷⁸⁴,Roper David I.⁹²³⁴,Shepherd Samantha L.⁶⁷⁸⁴,Simpson Daniel H.¹²³⁴⁹,Waterfield Nicholas R.¹⁰²³⁴,Scott Peter¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Warwick

3. Coventry

4. UK

5. Institute of Advanced Study

6. School of Applied Sciences

7. University of Huddersfield

8. Huddersfield

9. School of Life Sciences

10. Warwick Medical School

Abstract

New optically pure helicate-like architectures are extremely active against cancer cell lines, with IC₅₀ values as low as 40 nM, but nearly three orders of magnitude less active against healthy cells. There is also low toxicity to microbes and amoeba.

Funder

University of Warwick

Institute for Advanced Study

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC03677A

Reference48 articles.

1. Cancer multidrug resistance