Dicobalt(<scp>ii</scp>) helices kill colon cancer cells <i>via</i> enantiomer-specific mechanisms; DNA damage or microtubule disruption-Reference-Cited by-同舟云学术

Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption

Published:2024 Issue:28 Volume:15 Page:11029-11037
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Song Hualong¹²^ORCID,Kostrhunova Hana³^ORCID,Cervinka Jakub³⁴^ORCID,Macpherson Julie²^ORCID,Malina Jaroslav³^ORCID,Rajan Teena²^ORCID,Phillips Roger⁵^ORCID,Postings Miles²^ORCID,Shepherd Samantha⁵^ORCID,Zhang Xuejian⁶^ORCID,Brabec Viktor³⁷^ORCID,Rogers Nicola J.⁸^ORCID,Scott Peter²^ORCID

Affiliation:

1. Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Centre of Endogenous Prophylactic of Ministry of Education of China, School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, China

2. Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK

3. Czech Academy of Sciences, Institute of Biophysics, Brno, Czech Republic

4. Faculty of Science, Department of Biochemistry, Masaryk University, Brno, Czech Republic

5. Department of Pharmacy, University of Huddersfield, Huddersfield HD1 3DH, UK

6. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China

7. Department of Biophysics, Palacky University, Olomouc, Czech Republic

8. Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China

Abstract

Optically pure Co metallohelices exhibit high and selective potency against cancer cells but operate by different mechanisms; the Δ-enantiomer induces DNA damage in HCT116 cells while the Λ-enantiomer disrupts tubulin networks.

Funder

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

University of Warwick

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC02541E

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5. Anticancer metallohelices: nanomolar potency and high selectivity