Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle

Author:

van der Peet Phillip L.1234,Nagata Masahiro56789,Shah Sayali1234,White Jonathan M.1234,Yamasaki Sho56789,Williams Spencer J.1234

Affiliation:

1. School of Chemistry and Bio21 Molecular Science and Biotechnology Institute

2. University of Melbourne

3. Parkville

4. 3010 Australia

5. Division of Molecular Immunology

6. Medical Institute of Bioregulation

7. Kyushu University

8. Fukuoka 812-8582

9. Japan

Abstract

Complex, long-chain lipid structures are required for robust signalling of 6-O-acylglucoses through the pattern recognition receptor Mincle.

Funder

Japan Society for the Promotion of Science

Ministry of Health, Labour and Welfare

Ministry of Education, Culture, Sports, Science, and Technology

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference48 articles.

1. Signalling through C-type lectin receptors: shaping immune responses

2. The Dectin-2 family of C-type lectins in immunity and homeostasis

3. A. J. Foster , J. H.Bird, M. S. M.Timmer and B. L.Stocker, in C-Type Lectin Receptors in Immunity, ed. S. Yamasaki, Springer, Japan, 2016, ch. 13, pp. 191–215

4. MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns

5. M. Nagata , Z.Omahdi and S.Yamasaki, in C-Type Lectin Receptors in Immunity, ed. S. Yamasaki, Springer, Japan, 2016, ch. 2, pp. 15–34

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