Concise synthesis of spergualin-inspired molecules with broad-spectrum antibiotic activity-Reference-Cited by-同舟云学术

Concise synthesis of spergualin-inspired molecules with broad-spectrum antibiotic activity

Published:2015 Issue:5 Volume:6 Page:912-918
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Assimon Victoria A.¹²³⁴,Shao Hao⁵⁶⁴,Garneau-Tsodikova Sylvie⁷⁸⁹⁴,Gestwicki Jason E.¹²³⁴⁵

Affiliation:

1. Program in Chemical Biology

2. University of Michigan

3. Ann Arbor

4. USA

5. Department of Pharmaceutical Chemistry

6. University of California at San Francisco San Francisco

7. Department of Pharmaceutical Sciences

8. University of Kentucky

9. Lexington

Abstract

There is a growing need to identify new, broad-spectrum antibiotics. Here, we report a concise route to an antibiotic based on the privileged structure of the natural product spergualin.

Funder

National Institutes of Health

Directorate for Biological Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00572D

Reference15 articles.

1. A new antitumor antibiotic, spergualin: Isolation and antitumor activity.

2. Structure of an antitumor antibiotic, spergualin.

3. The impact of natural products upon modern drug discovery

4. The Crisis in Antibiotic Resistance

5. Drugs for bad bugs: confronting the challenges of antibacterial discovery

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