Near-infrared AIEgens with high singlet-oxygen yields for mitochondria-specific imaging and antitumor photodynamic therapy-Reference-Cited by-全球学者库

Near-infrared AIEgens with high singlet-oxygen yields for mitochondria-specific imaging and antitumor photodynamic therapy

Published:2023 Issue:25 Volume:14 Page:7076-7085
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhang Shasha¹,Yang Wenfang¹,Lu Xiao²,Zhang Xinyi¹,Pan Zhichao¹,Qu Da-Hui¹^ORCID,Mei Dong²,Mei Ju¹^ORCID,Tian He¹^ORCID

Affiliation:

1. Key Laboratory for Advanced Materials, Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, P. R. China

2. Clinical Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 56 South Lishi Road, Xicheng District, Beijing 100045, P. R. China

Abstract

Precisely engineering the electron donor in a twisted D–π–A system achieves mitochondria-targeting and AIE-active NIR photosensitizers with the 1O2 quantum yield up to 6.8 times that of Rose Bengal. NIR image-guided PDT has thus been realized.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Natural Science Foundation of Shanghai

Fundamental Research Funds for the Central Universities

Project 211

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00588G