Efficient synthesis of conformationally constrained, amino-triazoloazepinone-containing di- and tripeptides via a one-pot Ugi–Huisgen tandem reaction-Reference-Cited by-同舟云学术

Efficient synthesis of conformationally constrained, amino-triazoloazepinone-containing di- and tripeptides via a one-pot Ugi–Huisgen tandem reaction

Published:2014 Issue:36 Volume:12 Page:6986-6989
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Barlow T. M. A.¹²³⁴,Jida M.¹²³⁴,Tourwé D.¹²³⁴,Ballet S.¹²³⁴

Affiliation:

1. Research Group of Organic Chemistry

2. Departments of Chemistry and Bioengineering Sciences

3. Vrije Universiteit Brussel

4. B-1050 Brussels, Belgium

Abstract

Herein we describe a catalyst-free procedure employing an Ugi-4CR followed by a thermal azide–alkyne Huisgen cycloaddition to generate a 16-member library with up to four points of diversification and high atom economy.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01381F

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5. A Systematic Approach to the Optimization of Substrate-Based Inhibitors of the Hepatitis C Virus NS3 Protease: Discovery of Potent and Specific Tripeptide Inhibitors

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