The effect of polar headgroups and spacer length on the DNA transfection of cholesterol-based cationic lipids-Reference-Cited by-同舟云学术

The effect of polar headgroups and spacer length on the DNA transfection of cholesterol-based cationic lipids

Published:2020 Issue:2 Volume:11 Page:212-224
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Radchatawedchakoon Widchaya¹²³⁴⁵^ORCID,Thongbamrer Chopaka²³⁶⁷⁸,Konbamrung Wuttiphong¹²³⁴⁵,Khattawee Phakamas²³⁶⁷⁸,Sakee Uthai¹²³⁴⁵,Roobsoong Wanlapa⁹¹⁰¹¹⁷⁸^ORCID,Sattabongkot Jetsumon⁹¹⁰¹¹⁷⁸,Opanasopit Praneet¹²¹³¹⁴¹⁵⁸,Yingyongnarongkul Boon-ek²³⁶⁷⁸

Affiliation:

1. Creative Chemistry and Innovation Research Unit

2. Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC)

3. Faculty of Science

4. Mahasarakham University

5. Maha Sarakham

6. Ramkhamhaeng University

7. Bangkok

8. Thailand

9. Mahidol Vivax Research Unit

10. Faculty of Tropical Medicine

11. Mahidol University

12. Pharmaceutical Development of Green Innovations Group (PDGIG)

13. Faculty of Pharmacy

14. Silpakorn University

15. Nakhon Pathom

Abstract

Lysine-diamine-conjugated cholesterol-based cationic lipids with different headgroups and spacer lengths were synthesized. The active lipid was studied on the basis of transfection efficiency and physicochemical properties.

Funder

Mahasarakham University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00459A

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3. Synthetic Nucleic Acid Delivery Systems: Present and Perspectives