Synthesis, gene transfection efficiency, and serum compatibility of β-sitosterol-based cationic lipids with different headgroups-Reference-Cited by-同舟云学术

Synthesis, gene transfection efficiency, and serum compatibility of β-sitosterol-based cationic lipids with different headgroups

Published:2023 Issue:42 Volume:47 Page:19389-19403
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Thongbamrer Chopaka¹²^ORCID,Yingyongnarongkul Boon-ek²^ORCID,Sakee Uthai¹,Nguitragool Wang³⁴^ORCID,Radchatawedchakoon Widchaya¹^ORCID

Affiliation:

1. Creative Chemistry and Innovation Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahasarakham University, Maha Sarakham, 44150, Thailand

2. Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand

3. Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand

4. Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand

Abstract

We found that β-sitosterol-based cationic lipid 1B with sperminium headgroup exhibited high transfection potential into HEK293 cell lines in the presence of serum up to 40%.

Funder

Mahasarakham University

Center of Excellence for Innovation in Chemistry

Ministry of Higher Education, Science, Research and Innovation, Thailand

Faculty of Tropical Medicine, Mahidol University

Silpakorn University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ02503A

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