Stereoselective synthesis of 1,2-diamine containing indolines by a conjugate addition nitro-mannich reaction-Reference-Cited by-同舟云学术

Stereoselective synthesis of 1,2-diamine containing indolines by a conjugate addition nitro-mannich reaction

Published:2015 Issue:1 Volume:13 Page:170-177
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Anderson James C.¹²³⁴,Campbell Ian B.⁵⁶⁷⁴,Campos Sebastien⁵⁶⁷⁴,Shannon Jonathan¹²³⁴,Tocher Derek A.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University College London

3. London

4. UK

5. GlaxoSmithKline

6. Medicines Research Centre

7. SG1 2NY Stevenage

Abstract

The sequential use of the conjugate addition nitro-Mannich reaction, nitro reduction and then Pd-catalyzed intramolecular cyclisation allows the concise, stereodivergent synthesis of complex indolines.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB01793E

Reference44 articles.

1. Nitro-Mannich Reaction

2. Catalytic Enantioselective Aza‐Henry Reactions

3. Nickel boride/hydrazine hydrate reduction of aromatic and aliphatic nitro compounds. Synthesis of 4-(benzyloxy)indole and .alpha.-alkyltryptamines

4. Rapid stereoselective reduction of thermally labile 2-aminonitroalkanes.

5. Transfer hydrogenation: A stereospecific method for the conversion of nitro alkanes into amines

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