<i>O</i>-Sulfation disposition of curcumin and quercetin in SULT1A3 overexpressing HEK293 cells: the role of arylsulfatase B in cellular <i>O</i>-sulfation regulated by transporters-Reference-Cited by-同舟云学术

O-Sulfation disposition of curcumin and quercetin in SULT1A3 overexpressing HEK293 cells: the role of arylsulfatase B in cellular O-sulfation regulated by transporters

Published:2022 Issue:20 Volume:13 Page:10558-10573
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Pei Shuhua¹,Dou Yuanyuan¹,Zhang Wenke¹,Qi Defei¹,Li Yingying¹,Wang Mengqing¹,Li Wenqi¹,Shi Hongxiang¹,Gao Zixuan¹,Yao Chaoyan¹,Fang Dong¹²,Sun Hua¹²^ORCID,Xie Songqiang²³

Affiliation:

1. School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China

2. Academy for advanced interdisciplinary studies, Henan University, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China

3. Institute of Chemical Biology, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China

Abstract

BCRP and MRP4 played a critical role in the cellular excretion of C-O-S and Q-O-S. Inhibited excretion of sulfate led to a reduced cellular sulfation, and ARSB has been proved to account for the transporter-dependent sulfation of curcumin and quercetin.

Funder

Key Technologies Research and Development Program

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO01436J

Reference58 articles.

1. From Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor Function