The influence of different carbonate ligands on the hydrolytic stability and reduction of platinum(iv) prodrugs-Reference-Cited by-同舟云学术

The influence of different carbonate ligands on the hydrolytic stability and reduction of platinum(iv) prodrugs

Published:2022 Issue:3 Volume:51 Page:885-897
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Chen Shu¹²,Ng Ka-Yan¹,Zhou Qiyuan¹²,Yao Houzong¹²,Deng Zhiqin¹²^ORCID,Tse Man-Kit¹,Zhu Guangyu¹²^ORCID

Affiliation:

1. Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People's Republic of China

2. City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, People's Republic of China

Abstract

The hydrolysis and reduction of Pt(iv) carbonates depend on the electron-withdrawing ability of the carbonates and the nature of the opposite axial ligands. The hydrolytic process for Pt(iv) carbonates proceeds by attacking the carbonyl carbon.

Funder

Research Grants Council, University Grants Committee

National Natural Science Foundation of China

Science, Technology and Innovation Commission of Shenzhen Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D1DT03959H

Reference36 articles.

1. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

2. Platinum(iv) anticancer prodrugs – hypotheses and facts

3. A view on multi-action Pt(IV) antitumor prodrugs

4. Recent advances in the synthesis, stability, and activation of platinum(IV) anticancer prodrugs

5. Platinum(IV) anticancer agents; are we en route to the holy grail or to a dead end?

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