Novel cytotoxic 1,10-phenanthroline–triterpenoid amphiphiles with supramolecular characteristics capable of coordinating <sup>64</sup>Cu(<scp>ii</scp>) labels-Reference-Cited by-同舟云学术

Novel cytotoxic 1,10-phenanthroline–triterpenoid amphiphiles with supramolecular characteristics capable of coordinating ⁶⁴Cu(ii) labels

Published:2022 Issue:41 Volume:20 Page:8157-8163
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bildziukevich Uladzimir¹,Özdemir Zulal¹^ORCID,Šaman David²,Vlk Martin³^ORCID,Šlouf Miroslav⁴,Rárová Lucie⁵,Wimmer Zdeněk¹⁶^ORCID

Affiliation:

1. Institute of Experimental Botany of the Czech Academy of Sciences, Isotope Laboratory, Vídeňská 1083, CZ-14220 Prague 4, Czech Republic

2. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 2, CZ-16610 Prague 6, Czech Republic

3. Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering, Břehová 7, CZ-11519 Prague 1, Czech Republic

4. Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovsky Sq. 2, CZ-16206 Prague 6, Czech Republic

5. Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic

6. University of Chemistry and Technology in Prague, Department of Chemistry of Natural Compounds, Technická 5, CZ-16628 Prague 6, Czech Republic

Abstract

Novel 1,10-phenanthroline–triterpenoid amphiphiles formed nano-assemblies in water, coordinated Cu(ii) and 64Cu(ii) salts for potential cancer monitoring and therapy, and displayed cytotoxicity partly dependent on the formation of nano-assemblies.

Funder

Vysoká Škola Chemicko-technologická v Praze

Technology Agency of the Czech Republic

Akademie Věd České Republiky

Ministerstvo Průmyslu a Obchodu

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01172G

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