Reversibility of the thia-Michael reaction of cytotoxic C5-curcuminoid and structure–activity relationship of bis-thiol-adducts thereof-Reference-Cited by-同舟云学术

Reversibility of the thia-Michael reaction of cytotoxic C5-curcuminoid and structure–activity relationship of bis-thiol-adducts thereof

Published:2016 Issue:45 Volume:14 Page:10683-10687
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kohyama Aki¹²³⁴,Fukuda Michihiro¹²³⁴,Sugiyama Shunsuke⁵⁶²⁷⁴,Yamakoshi Hiroyuki¹²³⁴,Kanoh Naoki¹²³⁴,Ishioka Chikashi⁵⁶²⁷⁴,Shibata Hiroyuki⁸⁹¹⁰⁴,Iwabuchi Yoshiharu¹²³⁴

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. Tohoku University

3. Sendai 980-8578

4. Japan

5. Institute of Development

6. Aging and Cancer

7. Sendai

8. Graduate School of Medicine

9. Akita University

10. Akita

Abstract

A panel of GO-Y030-bis-thiol-adducts were synthesized and the structure–reactivity relationship regarding the retro thia-Michael reaction as well as the cell growth inhibitory activity against human colon cancer HCT116 were evaluated.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science, and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01771A

Reference20 articles.

1. Managing the challenge of chemically reactive metabolites in drug development

2. Applying Mechanisms of Chemical Toxicity to Predict Drug Safety