A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy

Author:

Zhao Wei1,Fu Chao1,Gao Hanyi2,Zhou Yizhao3,Yan Caihong4,Yin Yuli1ORCID,Hu Rong1ORCID,Tang Ben Zhong5

Affiliation:

1. School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China

2. The Seventh Affiliated Hospital, University of South China/Hunan Provincial Veterans Administration Hospital, Hunan 421001, China

3. Department of Orthopedics, Hunan Provincial People's Hospital, The First-Affiliated Hospital of Hunan Normal University, Changsha 410005, China

4. The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China

5. School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, China

Abstract

An organic sonosensitizer bearing a low-energy gap and aggregation-induced emission features was constructed for efficient tumor therapy based on ultrasound irradiation triggered-ROS generation.

Funder

Natural Science Foundation of Hunan Province

Education Department of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

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