New reactions and processes for the efficient synthesis of a HCV NS5b prodrug-Reference-Cited by-同舟云学术

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New reactions and processes for the efficient synthesis of a HCV NS5b prodrug

Published:2018 Issue:11 Volume:20 Page:2519-2525
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Orr Robert K.¹²³⁴⁵^ORCID,McCabe Dunn Jamie M.¹²³⁴⁵^ORCID,Nolting Andrew¹²³⁴⁵,Hyde Alan M.¹²³⁴⁵^ORCID,Ashley Eric R.¹²³⁴⁵^ORCID,Leone Joseph¹²³⁴⁵,Sirota Eric¹²³⁴⁵,Jurica Jon A.¹²³⁴⁵^ORCID,Gibson Andrew¹²³⁴⁵,Wise Christopher¹²³⁴⁵,Oliver Steven¹²³⁴⁵,Ruck Rebecca T.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Process Research & Development

2. Merck & Co.

3. Inc.

4. Rahway

5. USA

Abstract

The evolution of synthetic chemistry approaches towards a green and sustainable synthesis of a HCV NS5b cyclic prodrug nucleoside (CPN) is described.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/GC/C8GC00102B

Reference19 articles.

1. The E Factor: fifteen years on

2. Escape from Flatland 2: complexity and promiscuity

3. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

4. What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

5. Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir

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