Discovering protein–protein interaction stabilisers by native mass spectrometry-Reference-Cited by-同舟云学术

Discovering protein–protein interaction stabilisers by native mass spectrometry

Published:2021 Issue:32 Volume:12 Page:10724-10731
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Bellamy-Carter Jeddidiah¹^ORCID,Mohata Manjari¹,Falcicchio Marta²^ORCID,Basran Jaswir³,Higuchi Yusuke⁴^ORCID,Doveston Richard G.²^ORCID,Leney Aneika C.¹^ORCID

Affiliation:

1. School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

2. Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, Leicester, LE1 7RH, UK

3. Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK

4. Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA

Abstract

Stabilising protein–protein interactions is challenging, yet therapeutically important. Native mass spectrometry can be used to monitor binding equilibria, allowing identification and measurement of novel protein–protein interaction stabilisers.

Funder

British Mass Spectrometry Society

Engineering and Physical Sciences Research Council

Royal Society

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01450A

Reference30 articles.