Affiliation:
1. Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK
Abstract
Measuring E3 ligase stoichiometry is important to decipher their mechanisms in protein degradation. Mass spectrometry reports on complexes involving CRBN or DCAF15, and the unexpected multimerization of DCAF15 that is governed by ionic strength.
Funder
UK Research and Innovation
University of Strathclyde
Engineering and Physical Sciences Research Council
Publisher
Royal Society of Chemistry (RSC)