A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster-Reference-Cited by-同舟云学术

A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster

Published:2017 Issue:38 Volume:46 Page:12785-12789
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Lu C.¹²³⁴⁵,Laws K.¹²³⁴^ORCID,Eskandari A.¹²³⁴,Suntharalingam K.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. King's College London

3. London

4. UK

5. College of Biological

Abstract

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties,1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency.

Funder

Leverhulme Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/DT/C7DT02789C

Reference32 articles.

1. The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

2. Cancer stem cells: an evolving concept

3. Tumour stem cells and drug resistance

4. Cancer's Perpetual Source?

5. Tackling the cancer stem cells — what challenges do they pose?

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