A continuous flow process for biaryls based on sequential Suzuki–Miyaura coupling and supercritical carbon dioxide extraction-Reference-Cited by-同舟云学术

A continuous flow process for biaryls based on sequential Suzuki–Miyaura coupling and supercritical carbon dioxide extraction

Published:2021 Issue:12 Volume:6 Page:2248-2252
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Ichitsuka Tomohiro¹^ORCID,Fujii Tatsuya¹^ORCID,Kobune Marina¹,Makino Takashi¹^ORCID,Kawasaki Shin-ichiro¹^ORCID

Affiliation:

1. Research Institute for Chemical Process Technology, National Institute of Advanced, Industrial Science and Technology (AIST), Nigatake 4-2-1, Sendai, Miyagi, 983-8551 Japan

Abstract

A continuous flow process for the production of biaryls based on the seamless coupling of a packed-bed reactor (synthesis module) and a rapid supercritical CO2 extraction system (extraction module) is reported.

Funder

New Energy and Industrial Technology Development Organization

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RE/D1RE00378J

Reference26 articles.

1. The Hitchhiker’s Guide to Flow Chemistry

2. Continuous manufacturing – the Green Chemistry promise?

3. A prototype continuous-flow liquid–liquid extraction system using open-source technology

4. End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts

5. Integrated plug flow synthesis and crystallisation of pyrazinamide

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