Integrated “lab-on-a-chip” microfluidic systems for isolation, enrichment, and analysis of cancer biomarkers

Author:

Surappa Sushruta1ORCID,Multani Priyanka1ORCID,Parlatan Ugur1,Sinawang Prima Dewi12ORCID,Kaifi Jussuf34,Akin Demir15,Demirci Utkan1ORCID

Affiliation:

1. Canary Center at Stanford for Cancer Early Detection, Bio-Acoustic MEMS in Medicine (BAMM) Lab, Department of Radiology, School of Medicine, Stanford University, Palo Alto, CA 94304, USA

2. Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA

3. Department of Surgery, School of Medicine, University of Missouri, Columbia, MO 65212, USA

4. Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA

5. Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD), School of Medicine, Stanford University, Stanford, CA 94305, USA

Abstract

This critical review addresses recent developments in integrated microfluidic technologies for cancer detection with an emphasis on three common subtypes of cancer biomarkers: circulating tumor cells, circulating tumor DNA and exosomes.

Funder

U.S. Army Medical Research Acquisition Activity

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference202 articles.

1. Cancer Facts & Figures 2022|American Cancer Society, https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2022.html , (accessed September 20, 2022)

2. S.Mukherjee , The Emperor of All Maladies: A Biography of Cancer , Simon and Schuster , 2010

3. The case for early detection

4. Early detection of cancer

5. Biomarkers in Cancer Staging, Prognosis and Treatment Selection

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