Early detection of cancer

Author:

Crosby David1ORCID,Bhatia Sangeeta23ORCID,Brindle Kevin M.45ORCID,Coussens Lisa M.67ORCID,Dive Caroline89ORCID,Emberton Mark10ORCID,Esener Sadik71112ORCID,Fitzgerald Rebecca C.13ORCID,Gambhir Sanjiv S.14ORCID,Kuhn Peter15ORCID,Rebbeck Timothy R.1617ORCID,Balasubramanian Shankar418ORCID

Affiliation:

1. Cancer Research UK (CRUK), London, UK.

2. Marble Center for Cancer Nanomedicine, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

3. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.

4. Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

5. Department of Biochemistry, University of Cambridge, Cambridge, UK.

6. Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR, USA.

7. Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.

8. Cancer Research UK Lung Cancer Centre of Excellence at the University of Manchester and University College London, University of Manchester, Manchester, UK.

9. CRUK Manchester Institute Cancer Biomarker Centre, University of Manchester, Manchester, UK.

10. Division of Surgery and Interventional Science, University College London, London, UK.

11. Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR, USA.

12. Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA.

13. Medical Research Council (MRC) Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK.

14. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.

15. USC Michelson Center Convergent Science Institute in Cancer, University of Southern California, Los Angeles, CA, USA.

16. Division of Population Science, Dana-Farber Cancer Institute, Boston, MA, USA.

17. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

18. Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.

Abstract

Survival improves when cancer is detected early. However, ~50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome. It is vital to better understand who is at greatest risk of developing cancer. We also need to elucidate the biology and trajectory of precancer and early cancer to identify consequential disease that requires intervention. Insights must be translated into sensitive and specific early detection technologies and be appropriately evaluated to support practical clinical implementation. Interdisciplinary collaboration is key; advances in technology and biological understanding highlight that it is time to accelerate early detection research and transform cancer survival.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference140 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. World Health Organization Fact sheet: Cancer; www.who.int/news-room/fact-sheets/detail/cancer.

3. Office for National Statistics UK Cancer survival by stage at diagnosis for England (experimental statistics): Adults diagnosed 2012 2013 and 2014 and followed up to 2015 10 June 2016; www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancersurvivalbystageatdiagnosisforenglandexperimentalstatistics/adultsdiagnosed20122013and2014andfollowedupto2015.

4. Colorectal cancer statistics, 2017

5. Stage at diagnosis of breast cancer in sub-Saharan Africa: a systematic review and meta-analysis

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3