Quick and easy access to N-Mannich bases of 1-isoindolinones by catalytic electroactivation of primary and secondary amines and tandem reaction with 2-formylbenzonitriles-Reference-Cited by-同舟云学术

Quick and easy access to N-Mannich bases of 1-isoindolinones by catalytic electroactivation of primary and secondary amines and tandem reaction with 2-formylbenzonitriles

Published:2015 Issue:1 Volume:39 Page:81-84
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Palombi Laura¹²³⁴,Di Mola Antonia⁵²³⁴,Massa Antonio¹²³⁴

Affiliation:

1. Dipartimento di Chimica e Biologia

2. Università di Salerno

3. 84084 Fisciano (Sa)

4. Italy

5. Dipartimento di Scienze Farmaceutiche

Abstract

Electrochemically initiated tandem reaction between 2-formylbenzonitriles and amines successfully leads toN-Mannich bases of 1-isoindolinones. Enantiopure isoindolinones have been obtained by resolution with chiral amines.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NJ/C4NJ01606H

Reference27 articles.

1. Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis

2. One-pot Synthesis and its Practical Application in Pharmaceutical Industry

3. Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity

4. Applications of MCR-Derived Heterocycles in Drug Discovery

5. One-Pot Reactions Accelerate the Synthesis of Active Pharmaceutical Ingredients

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