On Route to Diverse Nitrogen‐Bridged Polyhetero‐cycles with an N(acyl), N(aryl)‐acetal Core-Reference-Cited by-同舟云学术

On Route to Diverse Nitrogen‐Bridged Polyhetero‐cycles with an N(acyl), N(aryl)‐acetal Core

Published:2023-05-23 Issue:20 Volume:8 Page:
ISSN:2365-6549
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Author:

Morlacci Valerio¹,Caruso Tonino²,Chiarini Marco³,Marsicano Vincenzo¹,Arcadi Antonio¹,Palombi Laura¹^ORCID

Affiliation:

1. Dipartimento di Scienze Fisiche e Chimiche Università degli Studi di L'Aquila Via Vetoio 67100 Coppito (AQ) Italy

2. Dipartimento di Chimica e Biologia Università di Salerno Via Giovanni Paolo II, 132 84084 Fisciano Italy

3. Dipartimento di Bioscienze e Tecnologie Agroalimentari e Ambientali Università degli Studi di Teramo Via R. Balzarini 64100 Teramo Italy

Abstract

AbstractAn expeditious assembling of fused poly‐heterocyclic structures having a N(Acyl), N(aryl)‐Acetal core has been accomplished by cascade reaction of ortho‐functionalized anilines with 2‐formylbenzonitrile and subsequent intramolecular N‐amidic cyclization on different electrophilic carbons. The syntheses have been finalized using both cathodically‐initiated and conventional base‐catalyzed methods and comparing the two approaches in terms of substrate/product scope, efficiency, energy‐saving and sustainability in general.

Publisher

Wiley

Subject

General Chemistry

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