Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide-Reference-Cited by-同舟云学术

Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

Published:2022 Issue:56 Volume:58 Page:7769-7772
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Gómez-González Jacobo¹,Martínez-Castro Laura²^ORCID,Tolosa-Barrilero Juan³⁴^ORCID,Alcalde-Ordóñez Ana¹^ORCID,Learte-Aymamí Soraya¹^ORCID,Mascareñas José L.¹^ORCID,García-Martínez Joaquín C.³⁴^ORCID,Martínez-Costas José⁵^ORCID,Maréchal Jean-Didier²^ORCID,Vázquez López Miguel⁶^ORCID,Vázquez M. Eugenio¹^ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Spain

2. Insilichem, Departament de Química, Universitat Autònoma de Barcelona, 08193 Cerdanyola, Spain

3. Department of Inorganic, Organic Chemistry and Biochemistry, Faculty of Pharmacy, University of Castilla-La Mancha, 02071 Albacete, Spain

4. Regional Center for Biomedical Research (CRIB), 02071 Albacete, Spain

5. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Bioquímica y Biología Molecular, Universidade de Santiago de Compostela, Spain

6. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Inorgánica, Universidade de Santiago de Compostela, Spain

Abstract

We describe a new approach to target non-canonical DNA 3-Way Junctions (3WJs) that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.

Funder

Fundación Científica Asociación Española Contra el Cáncer

Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya

Junta de Comunidades de Castilla-La Mancha

Xunta de Galicia

Foundation for the National Institutes of Health

Ministerio de Ciencia e Innovación

Universidad de Castilla-La Mancha

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC02874C

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