The use of tyrosinases in a chemoenzymatic cascade as a peptide ligation strategy

Author:

Ni Yeke1,Wang Yu1,Tabor Alethea B.1ORCID,Ward John M.2ORCID,Hailes Helen C.1ORCID

Affiliation:

1. Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK

2. Department of Biochemical Engineering, University College London, Bernard Katz Building, Gower Street, London WC1E 6BT, UK

Abstract

A new N-terminal tyrosine-containing peptide ligation method has been developed utilising tyrosinase enzymes and a subsequent Pictet-Spengler reaction with aldehydes.

Funder

University College London

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Cell-free chemoenzymatic cascades with bio-based molecules;Current Opinion in Biotechnology;2024-02

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