Promoters <i>vs.</i> telomeres: AP-endonuclease 1 interactions with abasic sites in G-quadruplex folds depend on topology-Reference-Cited by-同舟云学术

Promoters vs. telomeres: AP-endonuclease 1 interactions with abasic sites in G-quadruplex folds depend on topology

Published:2023 Issue:4 Volume:4 Page:261-270
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Howpay Manage Shereen A.¹,Zhu Judy¹,Fleming Aaron M.¹,Burrows Cynthia J.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Utah, 315 S. 1400 E., Salt Lake City, UT 84112-0850, USA

Abstract

APE1 complexed with an abasic site in G-quadruplex (G4) topologies displays differences in binding constants, enzyme cleavage yields, and gene regulation. APE1 tightly binds parallel G4s to regulate transcription that is not found with hybrid G4s.

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D2CB00233G

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4. The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription

5. DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression

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