Asymmetric synthesis of 1-substituted 2-azaspiro[3.3]heptanes: important motifs for modern drug discovery-Reference-Cited by-同舟云学术

Asymmetric synthesis of 1-substituted 2-azaspiro[3.3]heptanes: important motifs for modern drug discovery

Published:2019 Issue:35 Volume:55 Page:5068-5070
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Reddy Leleti Rajender¹²³⁴⁵^ORCID,Waman Yogesh¹²³⁴⁵,Kallure Priya¹²³⁴⁵,Nalivela Kumara Swamy¹²³⁴⁵,Begum Zubeda¹²³⁴⁵,Divya Thumbar¹²³⁴⁵,Kotturi Sharadsrikar¹²³⁴⁵

Affiliation:

1. Route Scouting Department

2. Piramal Discovery Solutions

3. Pharmaceutical Special Economic Zone

4. Ahmedabad

5. India

Abstract

Highly diastereoselective addition of ethyl cyclobutanecarboxylate anions to Davis–Ellman's imines is reported. This methodology affords the preparation of enantiomerically and diastereomerically pure 1-substituted 2-azaspiro[3.3]heptanes, 1-substituted 2-azaspiro[3.4]octane and 1-substituted 2-azaspiro[3.5]nonane.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC00863B

Reference32 articles.

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3. 1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

4. Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

5. Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

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