A novel high-capacity immunoadsorbent with PAMAM dendritic spacer arms by click chemistry

Author:

Hu Xiaoyan1234,Li Guangji1234ORCID,Lin Yinlei5678ORCID

Affiliation:

1. School of Materials Science and Engineering

2. South China University of Technology

3. Guangzhou

4. China

5. School of Materials Science and Energy Engineering

6. Foshan University

7. Foshan

8. P. R. China

Abstract

A novel immunoadsorbent with polyamidoamine dendritic spacer arms was prepared. Click chemistry can improve the reaction selectivity between the ligands and the support matrix under mild reaction conditions. The designed and prepared immunoadsorbent exhibits excellent adsorption for IgG. The IgG adsorption capacity of Sep-G3-His is superior to those of Sep-triazole-His and protein A immunoadsorbents.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference40 articles.

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3. Effect of the Spacer Arm in Affinity Chromatography:  Determination of Adsorption Characteristics and Flow Rate Effect

4. Effect of Spacer Arm Length on Protein Retention on a Strong Cation Exchange Adsorbent

5. Influence of peptide ligand surface density and ethylene oxide spacer arm on the capture of porcine parvovirus

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