Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias-Reference-Cited by-同舟云学术

Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias

Published:2020 Issue:3 Volume:11 Page:392-410
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Sun Daniel L.¹²³⁴²,Poddar Soumya¹²³⁴²,Pan Roy D.¹²³⁴²^ORCID,Rosser Ethan W.¹²³⁴²^ORCID,Abt Evan R.¹²³⁴²,Van Valkenburgh Juno¹²³⁴²,Le Thuc M.¹²³⁴²,Lok Vincent¹²³,Hernandez Selena P.⁵²³,Song Janet¹²³,Li Joanna¹²³,Turlik Aneta⁵²³,Chen Xiaohong⁵²³,Cheng Chi-An⁵²³⁶²^ORCID,Chen Wei⁵²³,Mona Christine E.¹²³⁴²,Stuparu Andreea D.¹²³⁴²,Vergnes Laurent⁷⁸²³,Reue Karen⁷⁸²³⁹,Damoiseaux Robert¹⁰²¹¹³,Zink Jeffrey I.⁵²³^ORCID,Czernin Johannes¹²³⁴²,Donahue Timothy R.¹²³⁴²,Houk Kendall N.⁵²³^ORCID,Jung Michael E.⁵²³,Radu Caius G.¹²³⁴²^ORCID

Affiliation:

1. Department of Molecular and Medical Pharmacology

2. University of California, Los Angeles

3. USA

4. Ahmanson Translational Imaging Division

5. Department of Chemistry and Biochemistry

6. Department of Bioengineering

7. Department of Human Genetics

8. David Geffen School of Medicine

9. Molecular Biology Institute

10. UCLA Metabolomic Center

11. Los Angeles

Abstract

Potent α-N-heterocyclic carboxaldehyde thiosemicarbazone (HCT) antiproliferatives were synthesized through iterative rounds of methylation and fluorination modifications, with anticancer activities being potentiated by physiological levels of copper.

Funder

National Cancer Institute

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00594C

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2. Effect of chelating agents upon the synthesis of nucleic acids and protein: Inhibition of DNA synthesis by 1-formylisoquinoline thiosemicarbazone