Synergetic estrogen receptor-targeting liposome nanocarriers with anti-phagocytic properties for enhanced tumor theranostics

Author:

Wang Yuehua12345,Wang Zihua67895,Qian Yixia101112139,Fan Linyang101112139,Yue Chunyan101112139,Jia Fei101112139,Sun Jian12345,Hu Zhiyuan101112139,Wang Weizhi101112139ORCID

Affiliation:

1. School of Pharmaceutical Science and Technology

2. Health Science Platform

3. Tianjin University

4. Tianjin 300072

5. China

6. CAS Key Laboratory of Colloid

7. Interface and Chemical Thermodynamics

8. Institute of Chemistry Chinese Academy of Sciences

9. Beijing 100190

10. CAS Key Laboratory of Standardization and Measurement for Nanotechnology

11. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety

12. CAS Center for Excellence in Nanoscience

13. National Center for Nanoscience and Technology of China

Abstract

A synergetic targeted liposomal system which functionalized with both a tumor identification ligand and an immune targeting ligand was constructed. It could recognize and bind ER-positive breast cancer tissues in a specific way and reduce the macrophage phagocytosis of the nanoparticles.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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