Nanocapsules: An Emerging Drug Delivery System

Author:

Pandey Parijat1ORCID,Purohit Deepika2ORCID,Jalwal Pawan3ORCID,Manchanda Deeksha2ORCID,Saini Sapna4ORCID,Verma Ravinder5ORCID,Kaushik Deepak6ORCID,Mittal Vineet6ORCID,Kumar Manish7ORCID,Bhattacharya Tanima8ORCID,Rahman Md. Habibur9ORCID,Dutt Rohit5ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, Gurugram University, Gurugram, 122018, India

2. Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Rewari, 123401, India

3. Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Baba Mastnath University, Rohtak, 124001, India

4. PDM School of Pharmacy, Karsindhu, Jind, 126102, India

5. Department of Pharmacy, School of Medical and Allied Sciences, G.D. Goenka University, Gurugram, 122103, India

6. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India

7. MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University) Mullana, Ambala, 133207, India

8. Innovation, Incubation and Industry (i-cube) Laboratory, Techno India NJR Institute of Technology, Udaipur, 313003, Rajasthan, India

9. Department of Pharmacy, Southeast University, Banani, Dhaka, 1213, Bangladesh

Abstract

Background: Controlled drug release and site-specific delivery of drugs make nanocapsules the most approbative drug delivery system for various kinds of drugs, bioactive, protein, and peptide compounds. Nanocapsules (NCs) are spherical shape microscopic shells consisting of a core (solid or liquid) in which the drug is positioned in a cavity enclosed by a distinctive polymeric membrane. Objectives: The main objective of the present study is to elaborate on various formulation techniques and methods of nanocapsules (NCs). The review also spotlights various biomedical applications as well as on the patents of NCs till date. Methods: The review was extracted from the searches performed using various search engines such as PubMed, Google Patents, Medline, and Google Scholars, etc. In order to emphasize the importance of NCs, some published patents of NCs have been also reported in the review. Results: NCs are tiny magical shells having incredible reproducibility. Various techniques can be used to formulate NCs. The pharmaceutical performance of the formulated NCs can be judged by evaluating their shape, size, entrapment efficiency, loading capacity, etc. using different analytical techniques. Their main applications are found in the field of agrochemicals, genetic manipulation, cosmetics, hygiene items, strategic distribution of drugs to tumors, nanocapsule bandages to combat infection, and radiotherapy. Conclusion: In the present review, our team made a deliberate effort to summarize the recent advances in the field of NCs and focus on new patents related to the implementation of NCs delivery systems in the area of some life-threatening disorders like diabetes, cancer, and cardiovascular diseases.

Publisher

Bentham Science Publishers Ltd.

Subject

General Engineering,Condensed Matter Physics,General Materials Science

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