Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme-Reference-Cited by-同舟云学术

Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme

Published:2017 Issue:9 Volume:8 Page:6484-6492
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Latallo M. J.¹²³⁴,Cortina G. A.¹²³⁴⁵,Faham S.¹²³⁴,Nakamoto R. K.¹²³⁴,Kasson P. M.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Molecular Physiology

2. University of Virginia

3. Charlottesville

4. USA

5. Department of Biomedical Engineering

Abstract

Allosteric mutations increasingk_catin a beta lactamase act by changing conformational ensembles of active-site residues identified by machine learning.

Funder

National Institute of Allergy and Infectious Diseases

Google

Hartwell Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC02676E

Reference58 articles.

1. Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M β-Lactamases

2. Atomic Resolution Structures of CTX-M β-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability

3. W. H. Organization , Antimicrobial resistance: global report on surveillance, World Health Organization, 2014

4. Attributable Hospital Cost and Length of Stay Associated with Health Care-Associated Infections Caused by Antibiotic-Resistant Gram-Negative Bacteria

5. qnrB , Another Plasmid-Mediated Gene for Quinolone Resistance

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