Friends and relatives: insight into conformational regulation from orthologues and evolutionary lineages using KIF and KIN-Reference-Cited by-同舟云学术

Friends and relatives: insight into conformational regulation from orthologues and evolutionary lineages using KIF and KIN

Published:2024 Issue: Volume:252 Page:341-353
ISSN:1359-6640
Container-title:Faraday Discussions
language:en
Short-container-title:Faraday Discuss.

Author:

Yehorova Dariia¹^ORCID,Crean Rory M.²^ORCID,Kasson Peter M.³⁴⁵^ORCID,Kamerlin Shina Caroline Lynn¹^ORCID

Affiliation:

1. School of Chemistry and Biochemistry, Georgia Institute of Technology, USA

2. Department of Chemistry-BMC, Uppsala University, Sweden

3. Department of Biomedical Engineering, University of Virginia, USA

4. Department of Cell and Molecular Biology, Uppsala University, Sweden

5. Departments of Chemistry & Biochemistry and Biomedical Engineering, Georgia Institute of Technology, USA

Abstract

We have developed novel tools to characterize evolutionarily conserved non-covalent interactions in proteins. We showcase their application to understanding substrate specificity in class A β-lactamases, with potential impact for protein engineering.

Funder

Vetenskapsrådet

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FD/D4FD00018H

Reference46 articles.

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