Automated sulfur-[<sup>18</sup>F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform-Reference-Cited by-同舟云学术

Automated sulfur-[¹⁸F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform

Published:2023 Issue:10 Volume:8 Page:2403-2407
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Yang Zixuan¹,Barnes Chris¹,Domarkas Juozas²,Koch-Paszkowski Joanna²,Wright John²,Amgheib Ala¹,Renard Isaline²^ORCID,Fu Ruisi¹,Archibald Stephen²^ORCID,Aboagye Eric O.¹^ORCID,Allott Louis²^ORCID

Affiliation:

1. Comprehensive Cancer imaging Centre, Faculty of Medicine, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK

2. Centre for Biomedicine and Positron Emission Tomography Research Centre, Hull York Medical School and University of Hull, Cottingham Road, Hull, HU6 7RX, UK

Abstract

The sulfur-[18F]fluoride exchange reaction is a facile 19F/18F isotopic exchange labelling chemistry which is simple to automated for the preparation of positron emission tomography (PET) radiopharmaceuticals.

Funder

Royal Society of Chemistry

Royal Society

Medical Research Council

Engineering and Physical Sciences Research Council

Cancer Research UK

Imperial Experimental Cancer Medicine Centre

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00307H

Reference16 articles.

1. Late-stage [18F]fluorination: new solutions to old problems

2. The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

3. Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis

4. Convenient PET-tracer production via SuFEx 18F-fluorination of nanomolar precursor amounts

5. A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms