Base-mediated one-pot synthesis of 1,2,4-oxadiazoles from nitriles, aldehydes and hydroxylamine hydrochloride without addition of extra oxidant-Reference-Cited by-同舟云学术

Base-mediated one-pot synthesis of 1,2,4-oxadiazoles from nitriles, aldehydes and hydroxylamine hydrochloride without addition of extra oxidant

Published:2016 Issue:41 Volume:14 Page:9814-9822
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Wei¹²³⁴⁵,Xu Hao¹²³⁴⁵,Xu Yuanqing¹²³⁴⁵,Ding Tao¹²³⁴⁵,Zhang Wenkai¹²³⁴⁵,Ren Yanrong¹²³⁴⁵,Chang Haibo¹²³⁴⁵

Affiliation:

1. Institute of Fine Chemistry and Engineering

2. Henan Engineering Laboratory of Flame-retardant and Functional Materials

3. College of Chemistry and Chemical Engineering

4. Henan University

5. Kaifeng 475004

Abstract

The one-pot reactions include sequential base-mediated treatment of amidoxime with an aldehyde to form 4,5-dihydro-1,2,4-oxadiazole, and oxidization of the 4,5-dihydro-1,2,4-oxadiazole by another aldehyde to afford 1,2,4-oxadiazole.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01794K

Reference49 articles.

1. Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product

2. Recent Advances in the Chemistry of 1,2,4-OxadiazolesaaDedicated to Professor Nicolò Vivona on the occasion of his 75th birthday.

3. Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles

4. Oxadiazoles in Medicinal Chemistry

5. Design, synthesis, characterization, and antibacterial activity of {5-chloro-2-[(3-substitutedphenyl-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanones

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