2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development-Reference-Cited by-同舟云学术

2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development

Published:2014 Issue:73 Volume:4 Page:38726-38742
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Laube Markus¹²³⁴⁵,Tondera Christoph¹²³⁴⁵,Sharma Sai Kiran⁶⁷⁸⁹,Bechmann Nicole¹²³⁴⁵,Pietzsch Franz-Jacob¹²³⁴¹⁰,Pigorsch Arne¹¹¹²¹³¹⁴,Köckerling Martin¹¹¹²¹³¹⁴,Wuest Frank⁶⁷⁸⁹,Pietzsch Jens¹²³⁴⁵,Kniess Torsten¹²³⁴

Affiliation:

1. Department Radiopharmaceutical and Chemical Biology

2. Institute of Radiopharmaceutical Cancer Research

3. Helmholtz-Zentrum Dresden-Rossendorf

4. 01328 Dresden, Germany

5. Department of Chemistry and Food Chemistry

6. Department of Oncology

7. Cross Cancer Institute

8. University of Alberta

9. Edmonton, Canada T6G 1Z2

10. Centre for Translational Bone, Joint, and Soft Tissue Research

11. Department of Inorganic Solid State Chemistry

12. Institute of Chemistry

13. University of Rostock

14. 18059 Rostock, Germany

Abstract

A series of 2,3-diaryl-substituted indoles containing a fluorine or methoxy group was synthesized via Fischer indole synthesis, McMurry cyclization, or Bischler–Möhlau reaction to identify potential leads for PET radiotracer development.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA05650G

Reference60 articles.

1. The COXIB Experience: A Look in the Rearview Mirror

2. Current Status of COX-2 Inhibitors

3. Pyrazolylbenzyltriazoles as cyclooxygenase inhibitors: synthesis and biological evaluation as dual anti-inflammatory and antimicrobial agents

4. From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

5. Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors

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