Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion-Reference-Cited by-同舟云学术

Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion

Published:2016 Issue:1 Volume:8 Page:71-81
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Irvine Gordon W.¹²³,Pinter Tyler B. J.¹²³,Stillman Martin J.¹²³

Affiliation:

1. Department of Chemistry

2. The University of Western Ontario

3. London, Canada

Abstract

There are two competing pathways for the metalation of metallothionein MT1a by zinc and cadmium – a beaded pathway and a clustered pathway – adopted as a function of pH.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MT/C5MT00225G

Reference85 articles.

1. Copper Homeostasis at the Host-Pathogen Interface

2. The “magic numbers” of metallothionein

3. Copper: An essential metal in biology

4. Copper homeostasis in eukaryotes: Teetering on a tightrope

5. Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis

Cited by 48 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Human apo-metallothionein 1a is not a random coil: Evidence from guanidinium chloride, high temperature, and acidic pH unfolding studies;Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics;2024-07

2. Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview;Toxics;2024-03-20

3. Structural motifs in the early metallation steps of Zn(II) and Cd(II) binding to apo-metallothionein 1a;Journal of Inorganic Biochemistry;2024-02

4. Differentiated Zn(II) binding affinities in animal, plant, and bacterial metallothioneins define their zinc buffering capacity at physiological pZn;Metallomics;2023-10

5. Metallothionein-3 and carbonic anhydrase metalation properties with Zn(II) and Cd(II) change as a result of protein–protein interactions;Metallomics;2023-09-18