Zn-catalyzed hydrohydrazination of propargylamides with BocNHNH2: a novel entry into the 1,2,4-triazine core-Reference-Cited by-同舟云学术

Zn-catalyzed hydrohydrazination of propargylamides with BocNHNH2: a novel entry into the 1,2,4-triazine core

Published:2016 Issue:63 Volume:6 Page:57956-57959
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lukin Alexey¹²³⁴,Vedekhina Tatiana¹²³⁴,Tovpeko Dmitry¹²³⁴,Zhurilo Nikolay¹²³⁴,Krasavin Mikhail⁵⁶⁷

Affiliation:

1. Lomonosov Institute of Fine Chemical Tehnologies

2. Moscow Technological University

3. Moscow

4. 117571 Russian Federation

5. Saint Petersburg State University

6. Saint Petersburg

7. 199034 Russian Federation

Abstract

Hydrohydrazination of propargylamides with BocNHNH₂ under Zn(OTf)₂ catalysis gave dihydro-1,2,4-triazines which can be efficiently aromatized in situ with K₃[Fe(CN)₆]. This provides a new entry into the medicinally important 1,2,4-triazine core.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA12664B

Reference34 articles.

1. Zinc-Promoted Hydrohydrazination of Terminal Alkynes: An Efficient Domino Synthesis of Indoles

2. Ancillary ligand-free copper catalysed hydrohydrazination of terminal alkynes with NH2NH2

3. Mechanistic Dichotomy with Alkynes in the Formal Hydrohydrazination/Fischer Indolization Tandem Reaction Catalyzed by a Ph3PAuNTf2/pTSA Binary System

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