Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain-Reference-Cited by-同舟云学术

Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain

Published:2022 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Cardoso Fernanda C.¹,Schmit Matthieu²³^ORCID,Kuiper Michael J.⁴,Lewis Richard J.¹,Tuck Kellie L.²^ORCID,Duggan Peter J.³⁵^ORCID

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia

2. School of Chemistry, Monash University, Victoria 3800, Australia

3. CSIRO Manufacturing, Research Way, Clayton, Victoria 3168, Australia

4. CSIRO Data 61, Docklands, Vic 3008, Australia

5. College of Science and Engineering, Flinders University, Adelaide, South Australia 5042, Australia

Abstract

Experimental and theoretical evidence that the blockade of CaV2.2 ion channels by TCAs is partially responsible for their analgesic effects.

Funder

National Health and Medical Research Council

Monash University

Commonwealth Scientific and Industrial Research Organisation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00331C

Reference49 articles.

1. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action

2. A treatment algorithm for neuropathic pain

3. Antidepressants for the Treatment of Chronic Pain

4. An Update on the Pharmacological Management of Post-Herpetic Neuralgia and Painful Diabetic Neuropathy

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