Tricyclic antidepressant amitriptyline attenuates Ca<sup>2+</sup> responses in rat peritoneal macrophages-Reference-Cited by-同舟云学术

Tricyclic antidepressant amitriptyline attenuates Ca<sup>2+</sup> responses in rat peritoneal macrophages

Published:2024-03-15 Issue:2 Volume:66 Page:161-172
ISSN:0041-3771
Container-title:Цитология
language:
Short-container-title:Citologiâ

Author:

Milenina L. S.¹,Krutetskaya Z. I.¹,Antonov V. G.²,Krutetskaya N. I.¹

Affiliation:

1. St. Petersburg State University

2. St. Petersburg State Pediatric Medical University

Abstract

Amitriptyline is a tricyclic antidepressant widely used in clinical practice for the treatment of anxiety, depression and chronic pain. These drugs have a multifaceted effect on cellular processes. One of their targets is sigma-1 receptors. Sigma-1 receptors are molecular chaperones located in endoplasmic reticulum membrane; they are characterized by a unique structure and pharmacological profile. Sigma-1 receptors regulate many cellular processes in health and disease, including Ca2+ signaling. Using Fura-2AM microfluorimetry, it was shown for the first time that sigma-1 receptor agonist, antidepressant amitriptyline, significantly suppresses both Ca2+ mobilization from intracellular Ca2+-stores and subsequent store-dependent Ca2+ entry into cells, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, as well as disulfide-containing immunomodulators glutoxim and molixan, in rat peritoneal macrophages. The results suggest the involvement of sigma-1 receptors in a complex signaling cascade induced by glutoxim or molixan, leading to an increase of intracellular Ca2+ concentration in macrophages. The results also indicate the participation of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.

Publisher

The Russian Academy of Sciences

Reference98 articles.

1. Антушевич А.А., Антонов В.Г., Гребенюк А.Н., Антушевич А.Е., Ладанова Т.В., Бурова Е.Б. 2013. Патофизиологические основы эффективности глутоксима как средства сопровождения лучевой терапии рака ротоглотки. Вестник Рос. военно-мед. акад. Т. 3. № 43. С. 32. (Antushevich A.A., Antonov V.G., Grebenyuk A.N., Antushevich A.E., Ladanova T.V., Burova E.B. 2013. Pathophysiologic rationale of effectiveness of glutoxim supportive therapy add-on to radiotherapy management of oropharyngeal cancer. Vestnik Rossiiskoi Voenno-medicinskoi akademii. V. 3. № 43. P. 32.)

2. Борисов А.Е., Кожемякин Л.А., Антушевич А.Е, Кетлицкая О.С., Кащенко В.А., Чепур С.В., Кацалуха В.В., Васюкова Е.Л., Новиченков А.О., Мотущук И.Е. 2001. Клинико-экспериментальное обоснование регионарного и системного введения препаратов группы тиопоэтинов при циррозе печени. Вестник хирургии им. И.И. Грекова. Т. 4. № 2. С. 32. (Borisov A.E., Kozhemyakin L.A., Antushevich A.E., Ketliskaya O.S., Kashchenko V.A., Chepur S.V., Katsalucha V.V., Vasyukova E.L., Novichenkov A.O., Motushchuk I.E. 2001. Clinical and experimental grounds of the regional and systemic administration of the thiopoetin group medicines for cirrhosis of the liver. First communication. Vestnic hirurgii im. I.I. Grekova. V. 4. № 2. P. 32.)

3. Данилов Д.С. 2019. 70-летняя история трициклических антидепрессантов. Журнал неврологии и психиатрии им. С.С. Корсакова. Т. 119. № 12. С. 115. (Danilov D.S. 2019. 70-year history of tricyclic antidepressants. S.S. Korsakov. J. Neurol. Psychiatry. V. 119. № 12. P. 115.)

4. Крутецкая З.И., Миленина Л.С., Наумова А.А., Бутов С.Н., Антонов В.Г., Ноздрачев А.Д. 2017. Антагонист рецепторов сигма-1 галоперидол подавляет Са²⁺-ответы в макрофагах, вызываемые глутоксимом и моликсаном. Доклады Академии наук. Т. 472. № 6. С. 723. (Krutetskaya Z.I., Milenina L.S., Naumova A.A., Butov S.N., Antonov V.G., Nozdrachev A.D. 2017. Sigma-1 receptor antagonist haloperidol attenuates Ca²⁺ responses induced by glutoxim and molixan in macrophages. Doklady Biochem. Biophys. V. 472. P. 74.)

5. Крутецкая З.И., Миленина Л.С., Наумова А.А., Бутов С.Н., Антонов В.Г., Ноздрачев А.Д. 2018. Антагонист рецепторов сигма-1 галоперидол подавляет депо-зависимый вход Са²⁺ в макрофагах. Доклады Академии наук. Т. 480. № 5. С. 613. (Krutetskaya Z.I., Milenina L.S., Naumova A.A., Butov S.N., Antonov V.G., Nozdrachev A.D. 2018. Sigma-1 receptor antagonist haloperidol attenuates store-dependent Ca²⁺ entry in macrophages. Doklady Biochem. Biophys. V. 480. P. 162.)