Multicomponent, fragment-based synthesis of polyphenol-containing peptidomimetics and their inhibiting activity on beta-amyloid oligomerization-Reference-Cited by-同舟云学术

Multicomponent, fragment-based synthesis of polyphenol-containing peptidomimetics and their inhibiting activity on beta-amyloid oligomerization

Published:2017 Issue:44 Volume:15 Page:9331-9351
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lambruschini Chiara¹²³⁴^ORCID,Galante Denise⁵⁶⁷⁴^ORCID,Moni Lisa¹²³⁴^ORCID,Ferraro Francesco¹²³⁴,Gancia Giulio⁵⁶⁷⁴^ORCID,Riva Renata¹²³⁴^ORCID,Traverso Alessia¹²³⁴,Banfi Luca¹²³⁴^ORCID,D'Arrigo Cristina⁵⁶⁷⁴^ORCID

Affiliation:

1. Department of Chemistry and Industrial Chemistry

2. University of Genova

3. 16146 Genova

4. Italy

5. Istituto per lo Studio delle Macromolecole

6. Consiglio Nazionale delle Ricerche

7. 16149 Genova

Abstract

A new and short fragment-based approach towards artificial (but “natural-based”) complex polyphenols has been developed, exploiting the Ugi multicomponent reaction of phenol-containing simple substrates.

Funder

Fondazione Cariplo

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02182H

Reference55 articles.

1. Inhibition of protein aggregation and amyloid formation by small molecules

2. Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease

3. Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012)