Platinum(iv) dihydroxido diazido N-(heterocyclic)imine complexes are potently photocytotoxic when irradiated with visible light-Reference-Cited by-同舟云学术

Platinum(iv) dihydroxido diazido N-(heterocyclic)imine complexes are potently photocytotoxic when irradiated with visible light

Published:2019 Issue:37 Volume:10 Page:8610-8617
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shaili Evyenia¹²³⁴,Salassa Luca¹²³⁴^ORCID,Woods Julie A.⁵⁶⁷⁸⁴,Clarkson Guy¹²³⁴,Sadler Peter J.¹²³⁴^ORCID,Farrer Nicola J.⁹¹⁰¹¹⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Warwick

3. Coventry

4. UK

5. Photobiology Unit

6. Department of Dermatology and Photobiology

7. Ninewells Hospital

8. Dundee

9. Chemistry Research Laboratory

10. University of Oxford

11. Oxford

Abstract

Trans,trans,trans-[Pt(N₃)₂(OH)₂(4-picoline)₂] is potently photocytotoxic (λ_irr = 420 nm) towards cancer cell lines whilst being minimally toxic in the absence of irradiation.

Funder

Wellcome Trust

John Fell Fund, University of Oxford

Medical Research Council

Engineering and Physical Sciences Research Council

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC02644D

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